What's more, chronic fat consumption seems to shut down the production of NAPEs by the intestine, not their effectiveness in the brain:
Animals fed a high-fat diet for 35 days lose the normal increases in circulating NAPE after a fatty meal. That suggest that derangements in NAPE secretion associated with chronic high-fat feeding may contribute to diet-induced obesity precipitated by overexposure to triglyceride-rich foods. However, those animals still responded to NAPE treatment.So treatment with NAPEs may be useful in treating obesity by breaking the cycle of fat consumption.
I could use some of this stuff. Preferably with gravy.